Monthly Archives: October 2018

Electrophoretic drug delivery for seizure control

Journal: Science Advances

Authors: C. M. Proctor and G. G. Malliaras et al.

Affiliation: The University of Cambridge (UK)

Publication date: 2018.08.29

Summarized by Inyeol Yun

 

– Topics
v. Neural probes incorporation an ion pump for on-demand drug delivery and   electrodes for recording local neural activity. (Fig. 1)
v. Seizure-like events (SLE) were induced by local injection of 4-aminopryridine (4AP)
v. γ-aminobutryic acid (GABA) inhibit neural activity.

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<Fig. 1>

–Fabrication
v. Gold electrode: ion pump source electrode, PEDOT:PSS electrode : recording   electrophysiological activity (Fig. 2)

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<Fig. 2>

– Results
v. Ion transfer efficiency: ~10-3 nmol of GABA transported in few seconds (Fig. 3)

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<Fig. 3>

  v. Seizure control (Fig. 4)

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<Fig. 4>

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Low-Power, Electrochemically Tunable Graphene Synapses for Neuromorphic Computing

Journal: Advanced Materials

Authors: M. T. Sharbati and F. Xiong et al.

Affiliation: The University of Pittsburgh (USA)

Publication date: 2018.07.23

Summarized by Inyeol Yun

 

– Background
v. The neural network in a human brain has ≈1011 neurons. Each neuron is typically   connected to ≈5,000 to 10,000 other neurons through synapse.
v. Synapse plasticity is the ability of synapses to strengthen or weaken over time, in   response to increases or decreases in their activity (Wikipedia). It related to memory   function.
v. Typical artificial synapses cannot mimic the analog behaviors of biological synapses.
v. In this paper, authors demonstrate the synapse plasticity using “nano-battery”   technology. (Fig. 1)

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<Fig. 1>

– Structure & Fabrication
v. Graphene layers – Solid electrolyte (LiClO4 in poly(ethylene oxide) (PEO) – Lithium   iron phosphate (LFP) (Fig. 2)

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<Fig. 2>

 v. Metal contacts (80 nm of Cu) were defined by e-beam lithography and deposited   through e-beam evaporation.
v. Real image (Fig. 3)

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<Fig. 3>

– Results
v. Raman spectroscopy shows weakening of bond between graphene layers as   increasing Li-ion. (Fig. 4)

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<Fig. 4>

 v. Resistance change (Figure. 5)

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<Fig. 5>

Flexible wireless powered drug delivery system for targeted administration on cerebral cortex

Journal: Nano Energy

Authors: S. Sung and K. Lee et al.

Affiliation: KAIST (Republic of Korea)

Publication date: 2018.06.07

Summarized by Inyeol Yun

 

– Flexible wireless powered drug delivery system (Fig. 1)

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<Fig. 1>

– Device fabrication
v. Structure (Fig. 2)

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<Fig. 2>

 v. Steps (Fig. 3)

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<Fig. 3>

– Technical points
v. Heat transfer simulation (LLO damage x) (Fig.4)

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<Fig. 4>

 v. Gold membrane dissolution process (Fig. 5)

5a

5

<Fig. 5>

  v. Wireless power efficiency (Fig. 6)

6.png

<Fig. 6>