Accelerated Wound Healing on Skin by Electrical Stimulation with a Bioelectric Plaster

Journal: Advanced Healthcare Materials

Author: Hiroyuki Kai and Matsuhiko Nishizawa et al.

Affiliation: Tohoku University, Japan

Publication date: 2017.09.20

Summarized by Inyeol Yun


– Bioelectric Plaster (Fig. 1)
v. Wound healing on skin involves cell migration and proliferation in response to endogenous electric current.
v. External electrical stimulation is used to promote these biological processes for the treatment of chronic wounds.
v. An enzymatic biofuel cell (EBFC) that generates ionic current along the surface of the skin by enzymatic electrochemical reactions for more than 12h. (Fig. 2)


Fig. 1


Fig. 2


– Materials
v. Cathode : carbon fiber fabric coated with carbon nanotubes, on which reducing enzyme bilirubin oxidase
v. Anode : carbon fiber fabric coated with carbon nanotubes, on which oxidizing enzyme fructose dehydrogenase
v. Hydrogel : citrate buffer solutions with different concentrations of fructose.
v. Stretchable resistor : PEDOT/PU film


– Result
v. Time-dependent current changes of the bioelectric plaster with different external resistances and citrate buffer solutions with different concentrations. (Fig. 3)
v. Changes of wound width and height of Group A (gray), Group B (red), and Group C (blue) (Fig. 4)
v. Microscopy images of skin sections at the wound at day 7: a) the boundary between normal tissue and healed tissue, b) the area of normal tissue, c) the area of healed tissue, d) dermis, e) fat tissue (Fig. 5)  Group C > Group A on scar after healing, wound closure speed.


Fig. 3


Fig. 4


Fig. 5


– Reference
v. (accessed September 26, 2017)